Is there any relation between intrauterine growth restriction and platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV)? A prospective study

Cemile Dayangan Sayan; Mahmut İlkin Yeral

doi:10.21601/ortadogutipdergisi.391962

ORTADOĞU TIP DERGİSİ - ORTADOGU MEDICAL JOURNAL

Is there any relation between intrauterine growth restriction and platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV)? A prospective study

İntrauterin gelişme geriliği ile trombosit dağılım genişliği (PDW), platelet crit (PCT), ortalama trombosit hacmi (MPV) arasında bir ilişki var mı? Prospektif bir çalışma

Cemile Dayangan Sayan ¹ ^* , Mahmut İlkin Yeral ¹

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Ortadogu Tıp Derg, Volume 10, Issue 1, pp. 51-56

https://doi.org/10.21601/ortadogutipdergisi.391962

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Abstract

Aim: Intrauterine growth restriction (IUGR) is still an important pregnancy complication bringing on perinatal mortality and morbidity. Placental vascular dysfunction and subsequent obliteration of placental blood vessels are mostly accepted etiopathological factors of intrauterine growth restriction similar with preeclampsia. We aimed to investigate the possible difference between pregnant women suffering from intrauterine growth restriction and healty pregnant women for parameters of platelet count, platelet crit, platelet distribution crit and mean platelet volume.
Material and Method: This case- control study was conducted with 179 pregnant women. The study population was consisted of 94 pregnant women complicated with idiopathic IUGR (study group) and 85 healty pregnant women (control group). IUGR group was divided in two subgroups according to umbilical artery doppler velocimetry measurements. Complete blood count parameters including hemoglobin, platelet count, platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV) and white blood cell count (WBC) were measured.
Results: There was no significant difference between the groups for parameters of hemoglobin, PC and PCT. The mean amniotic fluid index of IUGR group was significantly lower than the control group (p=0.000). The mean WBC, MPV and PDW levels of IUGR group were significantly higher than the control group (p=0.013, p=0.047 and 0.035, respectively). The mean MPV level of IUGR group 1(umbilical artery S/D˃3) was significantly higher than that of IUGR group 2 (umbilical artery S/D<3) (p=0.045).
Conclusions: In the present study, we observed a significant difference between IUGR and healty pregnant women for platelet parameters of MPV and PDW. Beside this, we also observed higher MPV values in IUGR patients with increased umblical artery resistance compared to that in IUGR patients with normal umblical artery blood flow. Further studies are needed to discuss our results.

Keywords: Intrauterine growth restriction, pregnancy, platelet

Öz

Amaç: İntrauterin gelişme geriliği (IUGR) günümüzde halen önemli bir gebelik komplikasyonu olup, perinatal mortalite ve morbiditeye neden olur. Plasental vasküler disfonksiyon ve bunu takiben plasental kan damarlarının obliterasyonu, preeklampsi ile benzer şekilde çoğunlukla intrauterin büyüme kısıtlamasının etyopatolojik faktörleri olarak kabul edilmektedir. Bu çalışmada intrauterin gelişme geriliği olan gebeler ile sağlıklı gebeler arasında trombosit sayısı, trombosit kriteri, trombosit dağılım kriteri ve ortalama trombosit hacmi parametreleri açısından olası farkın araştırılması amaçlandı.
Gereç ve Yöntem: Bu vaka kontrol çalışması 179 gebe ile yürütülmüştür. Çalışma popülasyonu, idiyopatik İUGR ile komplike olan 94 gebe (çalışma grubu) ve 85 sağlıklı gebeden (kontrol grubu) oluşmaktadır. IUGR grubu umbilikal arter doppler velosimetri ölçümlerine göre iki alt gruba ayrıldı. Hemoglobin, trombosit sayısı, PDW, PCT, PC, MPV ve beyaz küre sayısı (WBC) gibi tam kan sayımı parametreleri ölçüldü.
Bulgular: Hemoglobin, PC ve PCT parametreleri açısından gruplar arasında anlamlı fark yoktu. IUGR grubunun ortalama amniotik sıvı indeksi kontrol grubuna göre anlamlı derecede düşüktü (p = 0.000). IUGR grubunun ortalama WBC, MPV ve PDW değerleri kontrol grubundan anlamlı derecede yüksekti (sırasıyla p = 0.013, p = 0.047 ve p= 0.035). IUGR 1. Grubunun (umbilikal arter S/D>3) ortalama MPV düzeyi IUGR 2. Grubununkinden (umbilikal arter S/D<3) anlamlı derecede yüksekti (p = 0.045).
Sonuçlar: Bu çalışmada, MPV ve PDW değerleri açısından İUGR olan gebeler ile sağlıklı gebeler arasında anlamlı bir farklılık olduğunu gözlemledik. Bunun yanında, normal umblikal arter kan akımına sahip IUGR hastalarıyla karşılaştırıldığında, umblikal arter direncinde artış bulunan IUGR hastalarında MPV değerleri daha yüksekti. Sonuçlarımız tartışmak için yeni çalışmalara ihtiyaç bulunmaktadır.

Keywords: İntrauterin gelişme geriliği, gebelik, platelet

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Citation

Dayangan Sayan C, Yeral Mİ. Is there any relation between intrauterine growth restriction and platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV)? A prospective study. Ortadogu Tıp Derg. 2018;10(1):51-6. https://doi.org/10.21601/ortadogutipdergisi.391962

Dayangan Sayan, C., & Yeral, M. İ. (2018). Is there any relation between intrauterine growth restriction and platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV)? A prospective study. Ortadoğu Tıp Dergisi, 10(1), 51-56. https://doi.org/10.21601/ortadogutipdergisi.391962

Dayangan Sayan, C., and Yeral, M. İ. (2018). Is there any relation between intrauterine growth restriction and platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV)? A prospective study. Ortadoğu Tıp Dergisi, 10(1), pp. 51-56. https://doi.org/10.21601/ortadogutipdergisi.391962

Dayangan Sayan C, Yeral Mİ. Is there any relation between intrauterine growth restriction and platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV)? A prospective study. Ortadogu Tıp Derg. 2018;10(1), 51-56. https://doi.org/10.21601/ortadogutipdergisi.391962

Dayangan Sayan, Cemile, and Mahmut İlkin Yeral. "Is there any relation between intrauterine growth restriction and platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV)? A prospective study". Ortadoğu Tıp Dergisi 2018 10 no. 1 (2018): 51-56. https://doi.org/10.21601/ortadogutipdergisi.391962

Dayangan Sayan, Cemile et al. "Is there any relation between intrauterine growth restriction and platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV)? A prospective study". Ortadoğu Tıp Dergisi, vol. 10, no. 1, 2018, pp. 51-56. https://doi.org/10.21601/ortadogutipdergisi.391962