Treatment  results of chronic delta hepatitis patients

Celal Ayaz; Tuğba Sarı

doi:10.21601/ortadogutipdergisi.494395

ORTADOĞU TIP DERGİSİ - ORTADOGU MEDICAL JOURNAL

Treatment results of chronic delta hepatitis patients

Kronik delta hepatitli hastalarımızın tedavi sonuçları

Celal Ayaz ¹, Tuğba Sarı ² ^*

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Ortadogu Tıp Derg, Volume 11, Issue 1, pp. 73-77

https://doi.org/10.21601/ortadogutipdergisi.494395

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Abstract

Aim: Chronic delta hepatitis has been reported in 2,3-2,7% of studies in our country. Chronic delta hepatitis cases progress rapidly and show poor prognosis and the rate of developing cirrhosis are 70% in 5-10 years. The success of interferon (IFN) based treatment regimens for the treatment of delta hepatitis is about 30%. However, there is frequent relapse at the end of therapy, unless HBsAg seroconversion is developed.
Material and Methods: In this study, patients with chronic Delta hepatitis were evaluated retrospectively and the patients who were treated successfully were reviewed by reviewing the literature. Anti-HDV was positive in 243 (4.44%) of 5471 HBsAg positive patients who applied between 2012-2017. Peg-IFN alpha 2a was given if dominated by HDV and Peg-IFN alpha 2a and tenofovir disoproksil were given if dominant by HBV.
Results: The patients who were treated were evaluated and at the end of the treatment 10 of the patients had HBs Ag seroconversion and anti-HBs were positive.
Conclusion: Effective and timely treatment of chronic hepatic hepatitis cases will prevent the complications related to liver failure and prevent death.

Keywords: delta hepatitis, hepatitis B, treatment

Öz

Amaç: Kronik delta hepatiti ülkemizde yapılan çalışmalarda %2,3-2,7 oranında bildirilmektedir. Kronik Delta hepatitli olgular hızlı ilerleyerek ve kötü prognoz gösterir ve 5-10 yıl içinde %70 oranında siroz gelişir. Delta hepatiti tedavisinde interferon (IFN) temelli tedavi rejimlerinin başarısı %30 civarındadır. Ancak tedaviyi sonlandırdıktan sonra HBsAg serokonversiyonu gelişmediği sürece sık relaps görülmektedir. Bu çalışmada kronik Delta hepatitli olgular retrospektif olarak incelenmiş ve tedavi başarısı sağlanan hastalar tartışılmıştır.
Gereç ve Yöntemler: 2012-2017 tarihleri arasında başvuran 5471 HBsAg pozitif hastanın 243’ünde (%4,44) Anti-HDV pozitifliği saptandı. Hastalara HDV dominant virüs ise Peg-IFN alfa 2a, HBV enfeksiyonu dominant ise Peg-IFN alfa 2a ve tenofovir disoproksil kombinasyonu verildi.
Bulgular: Tedavi verilen hastalar değerlendirildiğinde, tedavi sonrası 10’unda (%4,11) HBs Ag serokonversiyonu geliştiği ve Anti-HBs’nin pozitifleştiği görüldü.
Sonuç: kronik Delta hepatit olgularında etkili ve zamanında tedavi sağlanması ile karaciğer yetmezliğine bağlı komplikasyonları önleyebilir.

Keywords: delta hepatit, hepatit B, tedavi

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Citation

Ayaz C, Sarı T. Treatment results of chronic delta hepatitis patients. Ortadogu Tıp Derg. 2019;11(1):73-7. https://doi.org/10.21601/ortadogutipdergisi.494395

Ayaz, C., & Sarı, T. (2019). Treatment results of chronic delta hepatitis patients. Ortadoğu Tıp Dergisi, 11(1), 73-77. https://doi.org/10.21601/ortadogutipdergisi.494395

Ayaz, C., and Sarı, T. (2019). Treatment results of chronic delta hepatitis patients. Ortadoğu Tıp Dergisi, 11(1), pp. 73-77. https://doi.org/10.21601/ortadogutipdergisi.494395

Ayaz C, Sarı T. Treatment results of chronic delta hepatitis patients. Ortadogu Tıp Derg. 2019;11(1), 73-77. https://doi.org/10.21601/ortadogutipdergisi.494395

Ayaz, Celal, and Tuğba Sarı. "Treatment results of chronic delta hepatitis patients". Ortadoğu Tıp Dergisi 2019 11 no. 1 (2019): 73-77. https://doi.org/10.21601/ortadogutipdergisi.494395

Ayaz, Celal et al. "Treatment results of chronic delta hepatitis patients". Ortadoğu Tıp Dergisi, vol. 11, no. 1, 2019, pp. 73-77. https://doi.org/10.21601/ortadogutipdergisi.494395