Prognostic significance of Cyclin d1 / p16 / Ki-67 markers in bladder urothelial carcinomas

İlyas Sayar

doi:10.21601/ortadogutipdergisi.265416

ORTADOĞU TIP DERGİSİ - ORTADOGU MEDICAL JOURNAL

Prognostic significance of Cyclin d1 / p16 / Ki-67 markers in bladder urothelial carcinomas

Mesane ürotelyal karsinomlarında Siklin D1/p16/Ki-67 belirteçlerinin prognostik önemi

İlyas Sayar ¹ ^*

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Ortadogu Tıp Derg, Volume 9, Issue 2, pp. 73-78

https://doi.org/10.21601/ortadogutipdergisi.265416

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Abstract

Objectives: The results of a small number of studies on the expression of cyclin D1 / p16 / Ki-67 in urothelial carcinomas, either individually or in combination with each other, differ. In this study, the relationship between Cyclin d1 / p16 / Ki-67 markers in pathologic prognostic factors of bladder urothelial carcinoma was investigated.
Materials and methods: A total of 149 bladder urothelial carcinomas were selected from the pathology archive. In all cases, histopathological findings were reviewed and graded according to the WHO / ISUP system. Immunohistochemical staining for Cyclin d1 / p16 / Ki-67 was performed on a selected tissue block for each case.
Results: The rate of cyclin d1 staining was found to be higher in the first pT stage Ta-T1, low grade, recurrence and non-progressive cases. The rate of positivity is significantly higher in cases with high grade p16 staining, recurrence and high mortality. The Ki-67 staining rate is significantly lower than the first pT stage Ta-T1, low grade, high (score 3) incidence in cases without recurrence and progression, first pT stage T2-T4, high grade, recurrence and progression.
Conclusion: Cyclin d1 / p16 / Ki-67 markers in patients with bladder urothelial carcinoma have a statistically significant association with tumor grade and recurrence. Cyclin d1 / p16 / Ki-67 association may play a role in the progression and differentiation of urothelial carcinomas.

Keywords: Urothelial carcinoma, Cyclin D1, Ki- 67

Öz

ÖZ
Amaç: Ürotelyal karsinomların Siklin D1/p16/Ki-67 ekspresyonunu araştıran gerek ayrı ayrı ve gerekse ikili kombinasyonu ile yapılan az sayıda çalışmada sonuçlar farklılık göstermektedir. Bu çalışmada, mesane ürotelyal karsinomlarında Siklin D1/p16/Ki-67 belirteçlerinin patolojik prognostik faktörler ile ilişkisi araştırıldı.
Yöntem ve gereç: Toplam 149 mesane ürotelyal karsinomu patoloji arşivinden seçildi. Tüm olgularda histopatolojik bulgular tekrar gözden geçirildi ve WHO/ISUP sistemine göre derecelendirme uygulandı. Her olgu için seçilen bir doku bloğuna Siklin D1/p16/Ki-67 için immünhistokimyasal boyama işlemi gerçekleştirildi.
Bulgular: Siklin D1 boyanma oranı ilk pT evresi Ta-T1, düşük grade, rekürrens ve progresyon görülmeyen olgularda daha yüksek bulunmuştur. p16 boyanma oranı; yüksek grade, rekürrens görülen ve mortalite yüksek görülen olgularda anlamlı düzeyde yüksektir. Ki-67 boyanma oranı ise ilk pT evresi Ta-T1, düşük grade, rekürrens ve progresyon görülmeyen olgularda high (skor 3) görülme oranı, ilk pT evresi T2-T4, yüksek grade, rekürrens ve progresyon görülen olgulara göre anlamlı düzeyde düşüktür.
Sonuç: Mesane ürotelyal karsinomlu hastalarda Siklin D1/p16/Ki-67 belirteçlerinin tümörün yüksek gradeliği ve rekürrensiyle istatistiksel olarak anlamlı bir birliktelik vardır. Siklin D1/p16/Ki-67 birlikteliği ürotelyal karsinomların progresyonunda ve diferansiyasyonunda rol oynayabilir.

Keywords: Ürotelyal Karsinom, Siklin D1, Ki-67

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Citation

Sayar İ. Prognostic significance of Cyclin d1 / p16 / Ki-67 markers in bladder urothelial carcinomas. Ortadogu Tıp Derg. 2017;9(2):73-8. https://doi.org/10.21601/ortadogutipdergisi.265416

Sayar, İ. (2017). Prognostic significance of Cyclin d1 / p16 / Ki-67 markers in bladder urothelial carcinomas. Ortadoğu Tıp Dergisi, 9(2), 73-78. https://doi.org/10.21601/ortadogutipdergisi.265416

Sayar, İ. (2017). Prognostic significance of Cyclin d1 / p16 / Ki-67 markers in bladder urothelial carcinomas. Ortadoğu Tıp Dergisi, 9(2), pp. 73-78. https://doi.org/10.21601/ortadogutipdergisi.265416

Sayar İ. Prognostic significance of Cyclin d1 / p16 / Ki-67 markers in bladder urothelial carcinomas. Ortadogu Tıp Derg. 2017;9(2), 73-78. https://doi.org/10.21601/ortadogutipdergisi.265416

Sayar, İlyas. "Prognostic significance of Cyclin d1 / p16 / Ki-67 markers in bladder urothelial carcinomas". Ortadoğu Tıp Dergisi 2017 9 no. 2 (2017): 73-78. https://doi.org/10.21601/ortadogutipdergisi.265416

Sayar, İlyas "Prognostic significance of Cyclin d1 / p16 / Ki-67 markers in bladder urothelial carcinomas". Ortadoğu Tıp Dergisi, vol. 9, no. 2, 2017, pp. 73-78. https://doi.org/10.21601/ortadogutipdergisi.265416