Insidious danger in childhood era's: subclinical hypothyroidism
Çocukluk çağının gizli tehlikesi; subklinik hipotiroidi
Ayşegül Alpcan 1 * , Ayça Törel Ergür 2, Serkan Tursun 3
1 Kırıkkale Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları AD, Kırıkkale
2 Kırıkkale Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları AD, Çocuk Endokrinoloji BD, Kırıkkale
3 Özel Çankaya Yaşam Hastanesi, Çocuk Sağlığı ve Hastalıkları Bölümü, Ankara
* Corresponding Author
Ortadogu Tıp Derg, Volume 9, Issue 1, pp. 34-38
https://doi.org/10.21601/ortadogutipdergisi.293272
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Abstract
Thyroid hormones have an important role on the central nervous system, growth, development, body temperature regulation, metabolism of lipid, carbohydrate and energy, musculoskeletal system. The other hand, it has a different importance for its role in the myelinization of the central nervous system during the childhood period. Subclinical hypothyroidism (SH), is diagnosed when peripheral thyroid hormone levels are within normal reference laboratory range but serum thyroid-stimulating hormone levels are mildly elevated. Prevalance of subclinical hypothyroidism in chilhood is seen about %2. The majority of its etiology is due to the autoimmune thyroiditis and iodine deficiency. It is important to diagnose and treat the asymptomatic cases in a timely manner. Thyroxin treatment should be started if goiter, growth velocity is slowed down, decline in school success, negativism, depression, obesity, refractory iron deficiency anemia dyslipidemia, bone age retardation.
Öz
Tiroid hormonları; santral sinir sistemi gelişimi, büyüme, gelişme, vücut ısısı regülasyonu, lipit, karbonhidrat ve enerji metabolizması, iskelet sistemi üzerinde önemli role sahiptir. Diğer yönden çocukluk çağında santral sinir sistemi myelinizasyonunda görevli olduğu için önemi farklıdır. Subklinik hipotiroidi, serum tiroid stimulan hormon seviyesinin orta düzeyde artması ile birlikte serum tiroid hormon seviyelerinin normal referans laboratuvar aralığında olmasıdır. Çocuklarda %2 oranında görülmektedir. Etiyolojisinin büyük bir kısmını otoimmün tiroidit ve iyot eksikliği oluşturmaktadır. Asemptomatik olguların zamanında tanımlanması ve tedavisi önemlidir. Olgularda guatr, büyüme-gelişme geriliği veya duraksaması, ders başarısında azalma, negativizm, depresyon, obezite, demir eksikliği anemisi, dislipidemi, kemik yaşı geriliğinde levotiroksin tedavisi başlanması uygundur.
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