Giant Cell Carcinoma of the Lung: Management of Surgical Treatment

Funda İncekara; Ebru Sayılır Güven; Şevki Mustafa Demiröz; Merve Şengül İnan; Koray Aydoğdu; Funda Demirağ; Selim Şakir Erkmen Gülhan; Sadi Kaya; Göktürk Fındık

doi:10.21601/ortadogutipdergisi.440816

ORTADOĞU TIP DERGİSİ - ORTADOGU MEDICAL JOURNAL

Giant Cell Carcinoma of the Lung: Management of Surgical Treatment

Akciğerin dev hücreli tümörü: cerrahi tedavi yönetimi

Funda İncekara ¹ ^* , Ebru Sayılır Güven ¹, Şevki Mustafa Demiröz ¹, Merve Şengül İnan ¹, Koray Aydoğdu ², Funda Demirağ ³, Selim Şakir Erkmen Gülhan ¹, Sadi Kaya ¹, Göktürk Fındık ²

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Ortadogu Tıp Derg, Volume 11, Issue 2, pp. 125-130

https://doi.org/10.21601/ortadogutipdergisi.440816

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Abstract

Objectives: Pulmonary giant cell carcinoma (PGCC) is a histological type of nonsmall cell lung cancer and classified as one of the five subtypes of sarcomatoid carcinoma of the lung. Pure PGCC is very rare.
Material and Method: We represent our experience in the management of 7 patients (6 males and 1 female, with a range of 44-63 yr) with PGCC. The most representing symptoms were cough and hemoptysis. Upper lobectomy (n=7) and additionally mediastinal lymphadenectomy were performed in all patients.
Results: Definitive histological examination confirmed the diagnosis of PGCC in all cases. Even though there was no perioperative mortality, postoperative complications developed in a case were hemorrhage in the early perioperative period and bronchus fistula after two months from the operation. The mean survival of the patients was estimated as 28.8 months (38 days - 116 months).
Conclusion: The main treatment for PGCC is the complete surgical resection. Complete surgical resection was found to be usefull as a treatment of choice of PGCC in the early stage and contributed to survival.

Keywords: chemotherapy, giant cell carcinoma, radiotherapy, surgery, World Health Organization

Öz

Amaç: Pulmoner dev hücreli karsinom (PDHK) küçük hücreli dışı akciğer kanserinin bir histolojik tipidir ve akciğer sarkomatoid karsinomunun beş subtipinden biri olarak sınıflandırılır. Pür PDHK çok nadirdir.
Gereç ve Yöntem: Kliniğimizde PDHK nedeni ile tedavi gören 7 hastayla ilgili tecrübelerimizi sunduk (6 erkek ve 1 kadın, yaş aralığı 46-63 yıl). En sık görülen semptomlar öksürük ve hemoptizi idi. Üst lobektomi (n=7) ve ek olarak mediastinal lenfadenektomi bütün hastalara uygulandı.
Bulgular: Kesin histolojik inceleme ile tüm hastalarda PDHK tanısı doğrulandı. Herhangi bir perioperatif mortalite görülmemesine rağmen bir olguda ameliyat sonrası komplikasyon gelişti; erken perioperatif dönemde hemoraji ve operasyondan iki ay sonra bronşiyal fistül gelişti. Hastaların ortalama sağkalımı 28,8 ay (38 gün-116 ay) olarak bulundu.
Sonuç: PDHK için asıl tedavi komplet cerrahi rezeksiyondur. Komplet cerrahi rezeksiyonun erken evre PDHK için yararlı bir tedavi tercihi olduğu ve sağkalıma katkı sağladığı bulunmuştur.

Keywords: kemoterapi, dev hücreli karsinom, radyoterapi, cerrahi, Dünya Sağlık Örgütü

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Citation

İncekara F, Sayılır Güven E, Demiröz ŞM, Şengül İnan M, Aydoğdu K, Demirağ F, et al. Giant Cell Carcinoma of the Lung: Management of Surgical Treatment. Ortadogu Tıp Derg. 2019;11(2):125-30. https://doi.org/10.21601/ortadogutipdergisi.440816

İncekara, F., Sayılır Güven, E., Demiröz, Ş. M., Şengül İnan, M., Aydoğdu, K., Demirağ, F., Gülhan, S. Ş. E., Kaya, S., & Fındık, G. (2019). Giant Cell Carcinoma of the Lung: Management of Surgical Treatment. Ortadoğu Tıp Dergisi, 11(2), 125-130. https://doi.org/10.21601/ortadogutipdergisi.440816

İncekara, F., Sayılır Güven, E., Demiröz, Ş. M., Şengül İnan, M., Aydoğdu, K., Demirağ, F., . . . Fındık, G. (2019). Giant Cell Carcinoma of the Lung: Management of Surgical Treatment. Ortadoğu Tıp Dergisi, 11(2), pp. 125-130. https://doi.org/10.21601/ortadogutipdergisi.440816

İncekara F, Sayılır Güven E, Demiröz ŞM, et al. Giant Cell Carcinoma of the Lung: Management of Surgical Treatment. Ortadogu Tıp Derg. 2019;11(2), 125-130. https://doi.org/10.21601/ortadogutipdergisi.440816

İncekara, Funda, Ebru Sayılır Güven, Şevki Mustafa Demiröz, Merve Şengül İnan, Koray Aydoğdu, Funda Demirağ, Selim Şakir Erkmen Gülhan, Sadi Kaya, and Göktürk Fındık. "Giant Cell Carcinoma of the Lung: Management of Surgical Treatment". Ortadoğu Tıp Dergisi 2019 11 no. 2 (2019): 125-130. https://doi.org/10.21601/ortadogutipdergisi.440816

İncekara, Funda et al. "Giant Cell Carcinoma of the Lung: Management of Surgical Treatment". Ortadoğu Tıp Dergisi, vol. 11, no. 2, 2019, pp. 125-130. https://doi.org/10.21601/ortadogutipdergisi.440816